Placement Effect - SILVER
Before reading other responses -
Anise took a card from where it was supposed to be (her library), and put it into her hand. No game rule instructed her to do so, her opponent didn't say she could, and this is the first time the problem could be noticed. This will probably be GPE - DEC for Anise, with a penalty of Game Loss.
While it's kind of Nutmeg to offer her notes from Thoughtseize, we can't use them in this case. Anise's hand is currently a private zone, and we have to consider everything in that to be unknown. For that matter, even though the scry'd card *should* be the card on top of the stack that is Anise's hand, it's very dangerous to depend on this.
The only case I wouldn't consider this to be GPE - DEC is if the scry'd card was placed down such that it was touching the hand, but still obviously distinct.
After reading other responses -
There seems to be a consensus so far on GPE - DEC. It's worth remembering that while Game Loss is a severe penalty, there's a pretty big potential for abuse had Nutmeg not noticed where the scry'd card went.
reading the thread that Nathen linked, I don't believe that applies. The scenario in the thread, and what Scott was specifically referring to, was a situation where cards were technically in physical contact, but very clearly distinguishable.
This scenario, as described, has Anise's card is on top of a pile of other cards, in her hand. This sounds a lot more like it's no longer distinguishable.
We only have the description to go on, so it's hard to know “exactly how much” they are touching - but if I feel there's a reasonable opportunity to have performed slight-of-hand or otherwise mixed up the cards, then the card is in the hand.